CD-PRIME™

CD-PRIME™

The CD-PRIME™ Platform offers automated protocols for the enrichment of CTCs (circulating tumor cells) and cfDNA (cell-free DNA) derived from whole blood. Circulating tumor cells found in the blood samples of patients can be utilized for the diagnosis and prognosis of cancer using highly precise genetic analysis and cell quantification. Our advanced microfluidics technology enables various scenarios for liquid biopsy or simultaneous analyses of analytes.

Strengths

Quick and easy access to living CTCs using untreated blood and avoidance of cross-contamination.

Fully automated

Makes it possible to enrich living CTCs without special pretreatment of whole blood

No cross-contamination

Prevention of cross-contamination
of samples which may occur in various clinical situations through the use of a 1 sample 1 disc system

Easy-to-use

Full automation of blood processing procedures does not require a high-level of training, and CTCs and plasma can be obtained simultaneously for a more sensitive liquid biopsy.

Fully certified

Registered as a class 1 medical device with the Korean Ministry of Food and Drug Safety, US FDA (Food and Drug Administration), and CE (EU).

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WHY LIQUID BIOPSY

What is the liquid biopsy from Clinomics suitable for?

With this technique, CTCs and ctDNA can be isolated easily, so more precise information about a cancer’s progress can be obtained.

  • CTCs provide information about cell morphology and could be used if, FISH and Functional assay.
  • ctDNA is useful for the early detection of cancer and response monitoring and surveillance of cancer.
  • CTCs are suitable for DNA, RNA and protein biomarkers investigations.

User scenario

Product

CD-Lbx™ 1

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CD-Lbx™ 2

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CD-FAST™ Auto

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CD-OPR-2000™

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Required capacity

CD-Lbx™ 1

5-10 ml

glass

CD-Lbx™ 2

5-10 ml

glass

CD-FAST™ Auto

≤ 3 ml

glass

or Buffy coat from CD-LBx™ 1

CD-OPR-2000™

CTC

CD-Lbx™ 1

CD-Lbx™ 2

CD-FAST™ Auto

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CD-OPR-2000™

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Plasma

CD-Lbx™ 1

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CD-Lbx™ 2

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CD-FAST™ Auto

CD-OPR-2000™

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Buffy coat

CD-Lbx™ 1

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CD-Lbx™ 2

CD-FAST™ Auto

CD-OPR-2000™

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PBMC

CD-Lbx™ 1

CD-Lbx™ 2

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CD-FAST™ Auto

CD-OPR-2000™

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Platform

CD-Lbx™ 1

CD-OPR-2000™
(Automatic Platform)

CD-Lbx™ 2

CD-OPR-2000™
(Automatic Platform)

CD-FAST™ Auto

CD-OPR-2000™
(Automatic Platform)

CD-OPR-2000™

CD-OPR-2000™
(Automatic Platform)

Core technology

With the CD-PRIME™ system, the whole blood sample is injected into the inlet of the loading chamber, and the target CTCs are trapped on a membrane while the microfluidic disc rotates.

Isolation

Different cartridges are provided according to the method of blood separation and isolation of targeted particles.
Utility
  • A maximum of four cartridges can be used as blood chambers
  • Up to 10 ml of whole blood can be inserted per cartridge
  • The buffy coat separated from CD-LBx™ 1 is compatible for use with CD-FAST™ Auto for CTC enrichment
  • The end-user is able to do the downstream work such as NGS and PCR analysis according to the target
  • Fully automatic separation with the CD-OPR-2000™ device
Workflow
Utility
  • A maximum of four cartridges can be used as blood chambers
  • Up to 10 ml of whole blood can be inserted per cartridge
  • Inject Ficoll-Paque and whole blood into CD-LBx™ 2 to separate PBMCs and plasma
  • Simultaneous prep of plasma (for cfDNA), PBMCs
  • The end-user is able to do the downstream work such as NGS and PCR analysis according to the target
  • Fully automatic separation with the CD-OPR-2000™ device
Workflow

For research use only. Not to be used for diagnostic procedures. ©2019 Clinomics Inc.
All trademarks are the property of Clinomics Inc. IsoFluxSystem™ is a trademark of Fluxion Biosciences